Acquired Abnormalities (Stone Disease and Infection)

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Chapter 115

Acquired Abnormalities (Stone Disease and Infection)

Renal Infection

Acute Bacterial Pyelonephritis

Imaging: Renal cortical scintigraphy with technetium-99m dimercaptosuccinic acid (DMSA) or technetium-99m glucoheptonate is highly sensitive (at least 90%) for the detection of acute bacterial pyelonephritis. Infected regions of the kidneys have diminished or absent accumulation of the radiopharmaceutical agent, often with a spherical or flarelike pattern (Fig. 115-1). A renal abscess produces a scintigraphic defect that usually is indistinguishable from that of uncomplicated parenchymal infection.5,6

Contrast-enhanced computed tomography (CT) provides sensitivity that is similar to renal cortical scintigraphy for the diagnosis of acute bacterial pyelonephritis. Infected renal parenchyma has diminished contrast enhancement on images obtained immediately after injection of contrast material (Fig. 115-2). Potential patterns of infected parenchyma include radially oriented linear streaks of diminished attenuation, round or irregular hypoattenuating foci, wedge-shaped defects, and heterogeneous diminished enhancement throughout an enlarged kidney. The nephrogram intensity usually is diminished relative to the contralateral normal kidney. Delayed CT images of the infected kidney show retention of contrast in obstructed tubules. A parenchymal abscess appears as a hypoattenuating focus, sometimes with a prominently enhancing rim. A perinephric abscess also is hypoattenuating.7

Renal parenchymal edema resulting from infection leads to diminished signal intensity on T1-weighted magnetic resonance imaging (MRI) and increased signal intensity on T2-weighted images (Fig. 115-3). Nephromegaly or localized parenchymal expansion may be present. Corticomedullary differentiation is sometimes deficient. The parenchyma may have a striated appearance. Edema in the perinephric space is a common MRI finding. As with CT, contrast enhancement is deficient in the involved portions of parenchyma. Urothelial thickening is sometimes appreciable.8,9

Reported sensitivities of sonography for the detection of acute bacterial pyelonephritis range from 25% to 50%. The findings include nephromegaly, abnormal parenchymal echogenicity, loss of corticomedullary differentiation, renal sinus hyperechogenicity, and urothelial thickening. Color Doppler or power Doppler imaging demonstrates diminished perfusion of the infected regions of parenchyma, sometimes with a wedge shape (Fig. 115-4). A parenchymal abscess usually appears as a spherical hypoechoic focus with acoustic enhancement. Occasionally, pus within the cavity results in an isoechoic or hypoechoic appearance. A perinephric abscess appears as a hypoechoic fluid collection immediately peripheral to the capsule.1013

Pyonephrosis

Imaging: Sonography shows echogenic material within a dilated pelvocaliceal system (Fig. 115-5). The purulent material often layers in the dependent portions of the collecting system and may shift with changes in patient position. Thickening of the wall of the dilated renal pelvis usually is present. Uncommon additional potential findings include a fluid-debris level in the collecting system, echogenic foci due to gas-forming organisms, and complete filling of the dilated collecting system with echogenic material.17,18

Imaging of pyonephrosis with CT, MRI, or scintigraphy shows diminished function of the involved kidney. Deficient excretion of intravenously administered contrast or radiopharmaceutical material is noted. Contrast enhancement of the renal parenchyma of the infected kidney is heterogeneous and delayed on CT. Excreted contrast may outline filling defects in the dilated collecting system on delayed images. Debris usually is visible in the dilated renal collecting system on MRI. The renal parenchyma has abnormal heterogeneous signal intensity. The pus-filled collecting system is markedly hyperintense on diffusion-weighted images. Contrast-enhanced MRI confirms reduced function of the kidney.19

Xanthogranulomatous Pyelonephritis

Imaging: In the early stages of XGP, the involved portion of the kidney typically has an irregular hyperechoic character on sonography. With the diffuse form, the kidney may be massively enlarged but usually maintains a reniform shape. Echogenic foci with shadowing indicate the presence of calcifications. With progression, necrotic tissue and fluid are usually hypoechoic. Echogenic debris is sometimes visible within abscesses or the dilated collecting system.23

CT of diffuse XGP typically demonstrates an enlarged nonfunctioning kidney that has multiple low-attenuation parenchymal foci (Fig. 115-6). A staghorn calculus often is present in a contracted renal pelvis. Irregular contrast enhancement of the inflamed renal parenchyma occurs, often accompanied by inflammatory enhancement of the perinephric fat. Abscesses are moderately hypoattenuating and do not enhance with contrast. The pus-filled collecting system also is hypoattenuating. Little or no contrast excretion occurs. Regional retroperitoneal lymphadenopathy is common. With the focal form of XGP, CT typically demonstrates an expansile renal mass. Peripheral granulation tissue or compressed renal parenchyma may result in an enhancing peripheral rim. The involved renal parenchyma typically has low or intermediate signal intensity on T1-weighted MRI and high intensity on T2-weighted images.24

Candidiasis

Imaging: Potential sonographic findings of renal candidiasis include parenchymal hyperechogenicity, nephromegaly, one or more small abscesses, and debris within the collecting system. A fungus ball (mycetoma) in the pelvocaliceal system appears as an echogenic object, with or without acoustic shadowing (Fig. 115-7). Dilation of the collecting system proximal to a fungus ball is common. Findings on contrast-enhanced CT include nephromegaly, diffuse or multifocal edema, renal abscess, and hydronephrosis. Infected parenchyma lacks normal contrast enhancement. Disseminated candidiasis sometimes results in tiny bilateral renal lesions, which often are associated with splenic and hepatic disease. CT may demonstrate organ enlargement and a heterogeneous (salt and pepper) pattern of contrast enhancement.26,27

Tuberculosis

Imaging: In the acute phase of tuberculous infection, imaging of the renal parenchyma may be normal or show manifestations of edema and vasoconstriction. Involved areas lack normal contrast enhancement on CT and MRI and sometimes have altered echogenicity on sonography. Inflamed urothelium may appear thickened on cross-sectional imaging studies and undergo prominent contrast enhancement. Parenchymal edema and large tubercles may cause distortion of the calyceal system. Later in the course of the disease, compromised renal function results in diminished contrast excretion. Contrast sometimes pools within parenchymal cavitations. Multiple small filling defects may be present in the collecting system or ureter. Fibrotic strictures of the collecting system that are common late in the course of the disease result in focal dilation or hydronephrosis. Dystrophic calcifications develop in persons with necrotic parenchyma.29,30

Stone Disease

Nephrocalcinosis

Medullary Nephrocalcinosis

Overview: In more than 90% of children with nephrocalcinosis, the calcification predominantly is in the medullary region. The most common causes of medullary renal calcification in children are metabolic conditions such as renal tubular acidosis, diuretic use, and metabolic conditions that produce hypercalcemia and hypercalciuria (Box 115-1).3133

Etiologies, Pathophysiology, and Clinical Presentation: Type 1 renal tubular acidosis (RTA) is the most common metabolic condition associated with nephrocalcinosis in children. Nephrocalcinosis occurs in about three quarters of patients with type 1 RTA. Progression to urolithiasis can occur.

The long-term administration of loop diuretics, such as furosemide, is an important cause of nephrocalcinosis in neonates. The typical time course to the earliest manifestations of stone formation is approximately 30 days after the start of diuretic therapy. Spontaneous resolution occurs in most, but not all, of these infants within several months.

Medullary sponge kidney is an idiopathic developmental abnormality in which collecting tubule dilation occurs in one or more renal pyramids. Calcifications can form within the dilated collecting tubules, with the potential for migration into the pelvicalyceal system. Macroscopic renal calcifications are present in about 15% of patients with medullary sponge kidney.

Imaging: The major sonographic feature of medullary nephrocalcinosis is hyperechogenicity of one or more renal pyramids (Fig. 115-8). With macroscopic calcification, acoustic shadowing is present. The earliest sonographic sign of medullary nephrocalcinosis is loss of normal papillary hypoechogenicity. In some instances, hyperechogenicity occurs only at the tips of the pyramids.34,35

With extensive nephrocalcinosis, medullary calcifications are visible on standard radiographs. Most common are diffuse or uniform calcifications within the medullary pyramids, resulting in a triangular pattern. Renal calcification in patients with type 1 RTA typically is quite dense and involves all the medullary pyramids in a uniform fashion. Calcifications associated with medullary sponge kidney tend to be asymmetric.36

CT allows definitive localization of calcifications to the medullary or cortical regions (Fig. 115-9). With medullary sponge kidney, medullary calculi typically occur in clusters within the renal pyramids. Stagnation of contrast material is evident within the dilated collecting tubules on enhanced CT. With mild disease, stagnation of contrast material appears as linear papillary opacities; small cystic components may be visible with more advanced disease. With medullary sponge kidney, contrast material within the collecting tubules surrounds calculi. In patients with type 1 RTA, the contrast does not uniformly surround calcific deposits because the calcifications are within the medullary interstitium and tubular lumina.37

The Anderson-Carr-Randall progression theory of urolithiasis suggests that microscopic calcifications within a renal pyramid can coalesce to form a plaque that migrates toward the calyx and thereby form a stone nidus. High-resolution ultrasonography of young children may reveal papillary hyperechogenicity caused by these microscopic calcifications, despite normal findings on other imaging studies. Hyperechoic pyramids are present in about 50% of children with diseases that predispose to nephrocalcinosis. Subepithelial calcium phosphate plaques sometimes are visible on radiographs or CT as slivers of calcification adjacent to the papillary tip.38

Cortical Nephrocalcinosis

Overview and Imaging: Cortical nephrocalcinosis involves the periphery of the kidney and the central septa of Bertin. In the pure forms of cortical nephrocalcinosis, the medullary pyramids are spared. The most common causes of cortical nephrocalcinosis are chronic glomerulonephritis, acute cortical necrosis, and oxalosis (Box 115-2). Standard abdominal radiographs may show thin linear peripheral calcifications, diffuse homogeneous renal calcification, or diffuse punctate calcifications. On sonography, the involved cortex is echogenic, but acoustic shadowing does not occur unless conglomerate calcifications are present. CT accurately demonstrates the cortical location of calcification.33,39

Hyperoxaluria can cause nephrocalcinosis or nephrolithiasis. Renal calcifications in these patients often are predominantly cortical and can have a patchy or homogeneous character. Occasionally, calcification occurs throughout the cortical and medullary regions. During infancy, sonography may reveal enlarged hyperechoic kidneys without acoustic shadowing or other manifestation of macroscopic calcification. Eventually, parenchymal thickness decreases.

Cortical hyperechogenicity in patients with acute renal cortical necrosis may be visible on sonography within a few weeks of the injury. Calcifications become more obvious sonographically and radiographically over time. Progressive renal atrophy also occurs. Various patterns of nephrocalcinosis can occur in these patients: (1) punctate, (2) bandlike peripheral calcification with perpendicular extensions into the columns of Bertin, and (3) thin, parallel curvilinear calcifications at the interface between the necrotic cortex and the viable subcapsular cortex (i.e., the “tram-track” pattern).

Urolithiasis

Pathophysiology: About 70% of patients with urolithiasis have a known predisposing condition such as hypercalciuria, urinary stasis, or chronic infection (Table 115-1). A genitourinary anomaly is present in at least one third of children with nephrocalcinosis and in nearly all patients with renal calculi related to infection. Urolithiasis is common in patients with a urinary tract infection because of a urea-splitting gram-negative enteric organism. These “infection stones” usually are a mixture of magnesium ammonium phosphate (struvite) and calcium phosphate (apatite), that is, a “triple phosphate stone.” Struvite is the predominant composition of most staghorn calculi. Nonstruvite stones that occur in association with urinary tract infections are termed “infection-associated stones.” Patients with a neurogenic bladder, a congenital urinary tract obstruction, and other forms of urinary stasis have a propensity for calcium stones and infection stones.4345

Hypercalciuria is a common cause of calcium stones. Hyperoxaluria is an additional potential cause of urinary stones that contain calcium. Uric acid stones due to hyperuricosuria account for only 5% of stones in North American children, but they are common in some areas of the world (e.g., Israel). Cystinuria and xanthinuria are rare causes of urolithiasis. Matrix stones are rare stones that consist of nonradiopaque inspissated mucoproteins, usually in conjunction with laminated or scattered calcific components. About 30% of pediatric urolithiasis is idiopathic. The typical composition of idiopathic stones is calcium phosphate or calcium oxalate. Idiopathic calcium stones sometimes have a nucleus of urate.46

Bladder stones can either originate from the upper urinary tract or develop within the bladder (Fig. 115-10). Bladder stones often are laminated and sometimes reach a very large size. Bladder stones also can form in a bladder diverticulum, surgical pouch, or urachal remnant.

Urethral calculi are rare and only occur in males (Fig. 115-11). They can originate from a more proximal portion of the urinary tract or arise locally. Primary urethral calculi sometimes develop in association with prolonged obstruction or within a urethral diverticulum or the prostatic utricle.

Imaging: About 90% of urinary tract calculi are sufficiently radiopaque for visualization on standard radiographs (Table 115-2). Classification of a stone as radiopaque versus nonopaque (or radiolucent) is according to its appearance on standard radiographs (Fig. 115-12); most nonopaque stones are hyperattenuating on CT. In general, calcium stones are radiopaque. Stones composed of pure uric acid, xanthine, or struvite usually are nonopaque. Cystine stones are moderately radiopaque.47,48

Both radiopaque and nonopaque urinary tract stones appear echogenic on sonography and produce acoustic shadowing (Fig. 115-13). Sonography is sensitive for the detection of nephrolithiasis but is of limited utility for visualizing calculi in the ureters. An obstructing ureteral calculus usually is associated with some degree of ureteropelvocalyectasis, however. The sonographic appearance of acoustic shadowing aids in the differentiation of a bladder calculus from blood clot, debris, or tumor.

Multi-detector CT is the most sensitive imaging technique for the detection of urolithiasis (Fig. 115-14). Regardless of composition, nearly all urinary tract stones are hyperattenuating on CT. Calcium oxalate stones generally have attenuation values in the 800 to 1000 HU range, infection stones are in the 300 to 900 HU range, and uric acid stones usually measure between 150 to 500 HU. Secondary CT signs of an obstructing urinary tract stone include hydronephrosis, hydroureter, nephromegaly, delayed nephrogram, periureteral edema, and perinephric stranding or fluid. Usually, the portion of the ureteral wall that surrounds a calculus thickens (the “rim sign”); this sign typically is lacking with a phlebolith or other mimicking calcification. A linear soft tissue density (the involved pelvic vein) often extends from a phlebolith; this feature is the “comet tail sign.”47,49,50

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