A minimally invasive technique for tongue base stabilization

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Chapter 42 A minimally invasive technique for tongue base stabilization

1 INTRODUCTION

Obstructive sleep apnea syndrome (OSAS) results from a complex scenario initiated with airway collapse and obstruction, loss of compensatory wake and sleep reflexes, increased ventilatory effort, arousal, hypoventilation, and asphyxia during sleep. In adults, a structurally small upper airway may be a primary contributing factor. Enlarging this airway may prevent the cascade into sleep apnea and snoring.

The etiology of the small upper airway in adults may include an abnormal craniofacial structure, excessive soft tissue for the available space, and obesity. These abnormalities are not isolated to the upper pharynx and involve multiple upper airway segments. It has long been speculated that failure to treat these other areas of obstruction and collapse has been a cause of failure of isolated treatment with palatal surgery such as uvulopalatopharyngoplasty (UPPP). Hypopharyngeal levels of obstruction may include the structures of the tongue base, lateral hypopharynygeal walls, lingual tonsils and supraglottis. To treat these areas multiple procedures have been described. Each has varying levels of potential effectiveness and risks of morbidity. For surgeons the dilemma has been to adequately treat these observed sites of obstruction with the least morbidity.

Appropriate surgical treatment options require an understanding of the underlying airway abnormality. The pharyngeal wall is the posterior tongue. Its position stabilizes the hypopharynx, the lateral pharyngeal walls, and even the epipharynx. The tongue which in most mammals is an oral structure, in humans is unique and is also a pharyngeal structure. The human pharynx is potentially collapsible and is unique in requiring these muscles to maintain patency during sleep. The genioglossus and other tongue musculature do not just sustain speech and swallowing, but are ventilatory muscles supporting the airway during sleep.

Increasing stability of the tongue and lower pharynx may stabilize the airway during sleep and may effectively treat sleep-disordered breathing. Surgical procedures stiffen the airway, change shape, or increase volume of the airway. Procedures directed at the anterior wall of the pharynx include posterior glossectomy and advancement and suspension procedures. Skeletal osteotomies of the mandible may increase volume of the airway by advancing tissue or may stiffen by traction, muscle tension and stiffening. Glossectomy or tissue volume reduction procedures decrease tongue volume and proportionally increase airway size.

Most of these procedures are not widely applied. The absolute effect of any single procedure is variable. This combined with the perceived or actual morbidity discourages use to a relatively small population. The goal of surgery of the lower pharynx is to improve effectiveness, better define the surgical population, and decrease surgi-cal morbidity. The procedure of tongue base suspension is an option to treat lower pharyngeal obstruction and reduce morbidity compared to alternative procedures.

2 RATIONALE

Airway collapse during sleep is both dynamic and passive. Dynamic collapse occurs during inspiration. Passive collapse occurs during expiration. Both are the result of a combination of applied forces that collapse and dilate the airway. In a structurally small airway during sleep, when dilating forces that stabilize the airway are greater than the collapsing forces, the airway is obstructed.

Obstruction during sleep is the result of a complex cascade. During inspiration, upper (pharynx) and lower (chest wall and diaphragm) airway muscles are activated. The lower airway muscles create a negative intraluminal force balanced by upper airway muscles that stiffen and dilate the airway. Increases in negative airway pressure or loss of muscle dilation will obstruct the airway. In sleep-disordered breathing both occur. Increased upper airway resistance leads to more negative intraluminal pressure and activation of upper airway dilator muscles is delayed or decreased. During expiration, positive pressure forces dilate the airway, and upper airway muscle tone is reduced. If the balance is unfavorable and the effects of tissue mass are not compensated, collapse and obstruction occur.

The tipping point for apnea is poorly understood, but is likely initiated by passive expiratory collapse. It is this collapse that triggers the dynamic events during inspiration. Without passive airway collapse, the cascade of progressive inspiratory flow limitation, increased negative luminal pressure and increased upper airway resistance may be aborted. If adequate airway size is maintained during expiration, inspiratory obstruction is prevented.

Since during expiration the largest decreases in airway size occur in the hypopharynx, treatment of this segment may be critical for most if not all individuals with sleep-disordered breathing. The tongue suspension procedure was conceived as a means of providing an extraluminal dilating force to the lower pharyngeal airway in contrast to nasal Continuous Positive Airway Pressure (CPAP) which is an intraluminal dilating force. This is accomplished by passing a submucosal suture into the posterior midline tongue. The suture prevents passive collapse while not interfering with anterior and superior tongue movements which are involved with swallowing and speech. Placement is directed towards the level of the foramen cecum (Fig. 42.1).

3 TONGUE SUTURE SUSPENSION TECHNIQUE

3.1 STEP ONE (BONE ANCHOR)

The procedure is performed under general or local anesthesia. Local anesthesia requires an external approach. Technically, the procedure may be combined with other pharyngeal procedures. Due to tethering and edema of the tongue, this procedure may augment the pain and dysphagia of other procedures. Benefits of combined procedures must be balanced with risks of increased perioperative morbidity and increased side effects. Using the procedure as an isolated intervention is recommended until clinical experience is adequate. Since a foreign body is placed, preoperative broad-spectrum antibiotics to cover and intraoral closed wound are given Decadron 10 mg reduces tongue pain and swelling and postoperative nausea. Intubation may be oral or nasal depending on the surgeon’s experience and preference. With oral intubation, care must be taken to protect the endotracheal tube from damage or displacement. The oral cavity is prepped with antibacterial solutions such as chlorhexidine oral solution. Exposure is facilitated by using a shoulder roll. Local anesthesia is infused into the anterior midline floor of mouth anterior to Wharton’s ducts.

When performing the intraoral approach, an intraoral incision is made posterior to the salivary papillae (Fig. 42.2). The incision should be generous. An excessively long linear incision is easily closed with excellent healing. An incision too small for the device may result in mucosal tearing that may damage the papillae and create an intraoral scar. If an external incision is used an incision is made 1cm posterior to the gnathion in a convenient skin crease or shadow.

3.2 STEP TWO

The suture is anchored to the bone. Two methods may be used. One method is an intraoral approach using the Repose (Influ-ENT Ltd, Concord, NH) bone screwanchoring device. Alternatively the suture may be anchored externally using the Repose device or other methods to anchor the suture to the inferior mandible. The Repose bone screw system consists of the U-shaped bone screw inserter that is used to place the bone screw onto the lingual surface of the mandible through an incision in the floor of mouth. It also includes the self-tapping titanium screw which is attached to two 1-0 Prolene sutures (Ethicon Endo-Surgery, Inc., Cincinnati, OH) at its base. Lastly, a suture passer is included to pass the suture through the tongue base.

A tunnel is created by dissecting between the genioglossus muscle bellies in the midline with a curved or right angle mixture hemostat. Intraorally, dissection is posterior and deep to Wharton’s ducts and is carried palpably to bone. Soft tissue may be gently scraped from the bone at this juncture. If using the Repose device intraorally, placement of the bone screw inserter into the mouth may be difficult in an OSA patient. The back blunt end of the distal device may first be placed into the mouth. The bone-anchoring screw may then be placed into the intraoral incision and then through the midline tunnel down to bone. Care must be taken to place the bone screw below the tooth roots. Using force and orienting the screw perpendicular to the mandibular cortex, the driver is placed against the mandible and inserted with the battery-operated inserter (Fig. 42.3). Alternatively, a Prolene suture may be directly anchored by drilling two parallel holes in the inferior mandible. The end (s) of the suture may then be looped through this attachment.

3.3 STEP THREE

The suture that is attached to the mandible is then advanced to the tongue base about 1–1.5cm lateral to the midline with an awl or a suture passer (Fig. 42.4). An empty suture loop is passed in a similar manner on the opposite side of the tongue taking care to avoid the neurovascular bundle that lies laterally. The suture attached to the screw is then threaded onto an empty Mayo needle, inserted into its own exit site on the tongue base and passed submucosally to the exit site of the second suture so that it is threaded into the loop of the second suture (Fig. 42.5). The second suture (the empty suture loop) is then pulled back to the anterior attachment. The Prolene suture attached to the mandible now is in a triangular configuration (Fig. 42.6). The suture is tied to itself and the knot is buried (Fig. 42.7). It is important that the tension on this suture be enough to feel a dimple on the posterior tongue base, but not so great as to cause strangulation. The correct angulation is undetermined and whether effectiveness is altered based on an intraoral or external approach is not known.

5 DISCUSSION

Tongue suspension has been performed using various techniques. Suture suspension using the proprietary Repose™ device was introduced by DeRowe. The procedure’s concept is that the tongue suspension suture decreases compliance of the tongue. Airway space is not increasedbut posterior displacement is decreased during sleep. Thisstitch does not clinically alter normal tongue movement although limited anterior movement (such as withlicking an ice cream cone) can be decreased. Complica-tion rates of 15–20% have been reported and include edema, hematoma and infection. The suture is removable and reversible.

Published studies of tongue suspension to treat sleep apnea are primarily non-randomized, uncontrolled case series with short-duration follow-up. Most combine UPPP as part of the treatment. Extrapolating results is difficult (Table 42.1). In general, snoring and sleep-related outcomes improve. Snoring may still be bothersome. Postoperative morbidity includes moderate to severe pain, difficulty with speech, swallowing and drooling and transient VPI. Duration has been reported from 7 to 28 days. No long-term speech or swallowing problems were reported in the initial studies.

Complications include delayed floor of mouth sialadenitis, dehydration, delayed gastrointestinal bleeding, floor of mouth hematoma, and prolonged pain/infection leading to removal or loosening of the suture. Other complications include damage to the neurovascular bundle (lingual artery and hypoglossal nerve), osteomyelitis and damage to dental structures. To reduce the risk of these problems, perioperative antibiotics and steroids are recommended. A meticulous technique should be used to ensure that the neurovascular bundle and Wharton’s ducts are avoided and the suture buried.

REFERENCES

1. DeRowe A, Gunther E, Fibbi A, et al. Tongue-base suspension with a soft tissue-to-bone anchor for obstructive sleep apnea: preliminary clinical results of a new minimally invasive technique. Otolaryngol Head Neck Surg. 2000;122:100-103.

2. Woodson BT, DeRowe A, Hawke M, et al. Pharyngeal suspension suture with Repose bone screw for obstructive sleep apnea. Otolaryngol Head Neck Surg. 2000;122:395-401.

3. Woodson BT. A tongue suspension suture for obstructive sleep apnea and snorers. Otolaryngol Head Neck Surg. 2001;124:297-303.

4. Terris DJ, Kunda LD, Gonella MC. Minimally invasive tongue base surgery for obstructive sleep apnea. J Laryngol Otol. 2002;116(9):716-721.

5. Miller FR, Watson D, Malis D. Role of the tongue base suspension suture with The Repose System bone screw in the multilevel surgical management of obstructive sleep apnea. Otolaryngol Head Neck Surg. 2004;126(4):392-398. AU: Copy-ed has inserted year. Is 2004 correct?

6. Thomas AJ, Chavoya M, Terris DJ. Preliminary finding from a prospective. randomized trial of two tongue-base surgeries for sleep-disordered breathing, Otolaryngol Head Neck Surg. 2003;129(5):539-546.

7. Kuhnel TS, Schurr C, Wagner B, et al. Morphological changes of the posterior airway space after tongue base suspension. Laryngoscope. 2005;115(3):475-480.

8. Omur M, Ozturan D, Elez F, Unver C, Derman S. Tongue base suspension combined with UPPP in severe OSA patients. Otol Head Neck Surg. 2005;133:218-223.

9. Vicente E, Marin JM, Carrizzo S, Naya MJ. Tongue-base suspension in conjunction with uvulopalatopharyngoplasty for treatment of severe obstructive sleep apnea: long-term follow-up results. Laryngoscope. 2006;116(7):L1223-L1227.