Medication-Induced Movement Disorders

Published on 03/03/2015 by admin

Filed under Neurology

Last modified 03/03/2015

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41 Medication-Induced Movement Disorders

There are a large number of pharmaceutical agents with the potential to cause a movement disorder (Table 41-1). These medications primarily interfere with dopaminergic transmission within the basal ganglia (levodopa, dopamine agonists, dopamine receptor–blocking agents [DRBs]). Other classes of these movement disorder–inducing agents do not have as precisely defined biochemical mechanisms. These medications include central nervous system (CNS) stimulants, anticonvulsants, tricyclic antidepressants, and estrogens. From a clinical perspective, the medications most commonly responsible for iatrogenic movement disorders are the various neuroleptics and pharmacologic agents that block or stimulate dopamine receptors.

Table 41-1 Types of Drug-Induced Movement Disorders and Responsible Medications

Syndrome Responsible Medication
Postural tremor
Acute dystonic reactions
Akathisia
Parkinsonism
Chorea, including tardive and orofacial dyskinesia
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